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. 2003 Sep 30;89(7):1327–1333. doi: 10.1038/sj.bjc.6601262

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Copyright © 2003 Cancer Research UK

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5-Fluorouracil-induced cell death in RIF-1 cells in vivo. (A) Representative 5 μm immunohistochemical (TUNEL) sections of control and 5-FU treated (165 mg kg⁻¹ i.p.; 48 h postinjection) tumours; × 400 magnification. (B) The average number of apoptotic cells (TUNEL positive) per field of view (0.55 mm²) for control and 5-FU-treated groups. Two slices from three tumours were analysed for each group; for each section, 10 fields of view were randomly selected for the analysis. (C) Mean tumour size of pretreated (control) and 5-FU-treated (165 mg kg⁻¹ i.p.; 48 h postinjection) mice. There was a 43% reduction of tumour volume. Data are mean±s.e.m. (n=6, pretreated; n=3, 5-FU-treated).