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. 2003 Sep 30;89(7):1383–1388. doi: 10.1038/sj.bjc.6601276

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Copyright © 2003 Cancer Research UK

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Effect of reserpine and clomipramine on¹²³I-MIBG binding to cultured cell lines. Results are given as the percentage (mean±s.e.m.) of administered activity per microgram DNA (%AA μg⁻¹). The uptake in GOT1, BON and Colo205 cells was 4.0, 1.1 and 1.1%AA μg⁻¹ DNA, respectively. The VMAT antagonist reserpine significantly inhibited the binding in the NE tumour cell lines GOT1 and BON, whereas it had no effect on the non-NE tumour cell line Colo205. Clomipramine had no significant effect on the binding of ¹²³I-MIBG in any of the cell lines investigated.