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. 2003 Oct 14;89(8):1463–1472. doi: 10.1038/sj.bjc.6601243

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Copyright © 2003 Cancer Research UK

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Cytokine production by peripheral blood DCs in breast cancer patients compared with control subjects. A significantly lower percentage of PB DCs producing IL-12 upon LPS stimulation was observed in cancer patients. After incubation for 5 h in the presence or absence of LPS with BFA added during the last 4 h, whole-blood samples were stained with a cocktail of FITC-conjugated mAbs recognising CD3, CD14, CD16, CD19 and CD20, and with PerCP-conjugated anti-HLA-DR mAb. Intracellular accumulation of cytokines within DCs, identified as lineage-/HLA-DR+ cells, was evaluated after staining with PE-conjugated mAbs directed against either IL-12 or IL-10. Each symbol represents a single sample. Open circles: control subjects; open triangles: breast cancer patients. LPS-induced IL-12 values referred to the right axis; all the other values to the left axis. Mean values represented by horizontal lines in each series. P-values were determined using the t-test for independent samples, patients compared with controls.