Table 1. IC50 in AD and AI cells in response to the treatment of either paclitaxel or vinorelbine alone for 7 days, or paclitaxel for 3 days followed by vinorelbine for additional 4 days.
Cell lines | Treatment | IC50 (nM) | P-value |
---|---|---|---|
AD | Paclitaxel (T) | 0.035±0.005 | Tvs N, P<0.01 |
AD | NVB (N) | 0.310±0.061 | T vs T+N, P<0.001 |
AD | Paclitaxel followed by T + N | 0.0015±0.0007 | N vs T+N, P<0.001 |
AI | Paclitaxel (T) | 0.650±0.140 | T vs N, P>0.05 |
AI | NVB (N) | 0.590±0.091 | T vs T+N, P<0.001 |
AI | Paclitaxel followed by T + N | 0.110±0.003 | N vs T+N, P<0.001 |
The IC50 was calculated and statistically analysed between the treatments using PC program Sigma Plot from three separate experiments. T=treated with paclitaxel, N=treated with vinorelbine (NVB), and T+N=treated with paclitaxel followed by paclitaxel plus NVB as described in ‘Materials and Methods’.