Table 4. Maximum toxicity per patient.
| Grade 3 and 4 toxicitya | All patients, n=66 (%) | Oxaliplatin-based regimen, n=44 (%) | Irinotecan-based regimen, n=22 (%) | Group 1, n=48 (%) | Group 2, n=18 (%) |
|---|---|---|---|---|---|
| Any grades 3 and 4 (except alopecia) | 28 (42) | 16 (36) | 12 (54) | 20 (42) | 8 (44) |
| Neutropenia | 11 (17) | 6 (14) | 5 (23) | 8 (17) | 3 (17) |
| Thrombopenia | 4 (6) | 4 (9) | 0 | 2 (4) | 2 (11) |
| Anaemia | 1 (1.5) | 1 (2) | 0 | 1 (2) | 0 |
| Nausea and vomiting | 5 (8) | 3 (7) | 2 (9) | 4 (8) | 1 (6) |
| Diarrhoea | 10 (15) | 4 (9) | 6 (27) | 7 (15) | 2 (11) |
| Stomatitis | 2 (3) | 2 (5) | 0 | 2 (4) | 0 |
| Neurologic | 7 (11) | 7 (16) | 0 | 5 (10) | 2 (11) |
| Treatment interruption for toxicity | 11 (17) | 8 (18) | 3 (14) | 9 (19) | 2 (11) |
| Number of delayed cycles for toxicity/total number of cycles | 38/545 (7) | 24/309 (8) | 14/236 (6) | 27/411 (7) | 11/134 (8) |
a
According to WHO grade.