Table 1. Parameters of cellular radiosensitivity and cell cycle distribution.
0 Gy |
150 Gy |
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Cell lines | SF2a | α (Gy−1)b | β (Gy−2)b | Dbar (Gy)c | Gd1 | S | G2/M | G1 | S | G2/M |
RT112 | 0.62±0.02 | 0.18±0.06 | 0.028±0.007 | 3.2±0.5 | 55 | 33 | 13 | 43 | 54 | 2 |
DU145 | 0.63±0.05 | 0.12±0.02 | 0.055±0.005 | 2.85±0.3 | 54 | 36 | 10 | 47 | 44 | 9 |
SSC4451 | 0.41±0.07 | 0.38±0.15 | 0.032±0.018 | 2.04±0.5 | 80 | 11 | 9 | 83 | 10 | 7 |
HeLa | 0.43±0.03 | 0.33±0.06 | 0.043±0.007 | 2.1±0.2 | 70 | 18 | 12 | 43 | 40 | 17 |
LNCaP | 0.17±0.01 | 0.87±0.06 | 0.014±0.011 | 1.11±0.1 | 78 | 15 | 7 | 68 | 23 | 9 |
T47D-B8 | 0.46±0.06 | 0.29±0.4 | 0.045±0.006 | 2.21±0.2 | 65 | 26 | 9 | 53 | 14 | 33 |
MCF-7 | 0.53±0.06 | 0.16±0.04 | 0.078±0.006 | 2.35±0.3 | 73 | 16 | 11 | 60 | 25 | 15 |
MCF7-BB | 0.51±0.05 | 0.28±0.03 | 0.027±0.005 | 2.55±0.1 | 47 | 43 | 10 | 70 | 16 | 14 |
MCF7-Bus | 0.31±0.03 | 0.52±0.03 | 0.03±0.005 | 1.64±0.1 | 76 | 14 | 10 | 52 | 3 | 13 |
Surviving fraction for a X-ray dose of 2 Gy.
Linear and quadratic term of the dose response.
Dbar, mean inactivation dose.
Percentage of cells in G1, S or G2M-phase 24 h after 0 or 150 Gy.