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. 2003 Jul 29;89(3):585–592. doi: 10.1038/sj.bjc.6601131

Figure 2.

Figure 2

Impact of ZD1839 (6 μM) and cisplatin–5FU (0.15 and 3.3 μM, respectively) on cell proliferation and related molecular markers: (A) time-related impact of drugs on cell proliferation, (B) effect of ZD1839 on cell cycle at 24 h, (C) influence of drugs and drug combinations on p21 and (D) influence of drugs and drug combinations on p27. White bars=controls; black bars=ZD1839; dark grey bars=cisplatin–5FU combination; clear grey bars=ZD1839–cisplatin–5FU combination. Combination schedule as indicated in the legend to Figure 1.