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. 2003 Jul 29;89(3):585–592. doi: 10.1038/sj.bjc.6601131

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Copyright © 2003 Cancer Research UK

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ZD1839 and cisplatin–5FU alone caused an upregulation of Bax (A) and a downregulation of Bcl2 (B), and no additive effect was observed when ZD1839 was combined with cisplatin–5FU. Results confirmed by the Bax/Bcl2 ratio (C). ^*P<0.05 vs control, bars indicate standard deviation from the mean of three separate experiments.