Table 2.

Tissue iron content (μg/g dry weight; n = 4–7)

HFE genotype	+/+	+/o	o/o
Liver
Iron deficient	a 193 ±  21 A		a 949 ± 368 B
Iron adequate	a 423 ± 114 A	a 417 ± 105 A	a 1656 ± 420 B
Iron overload	b 1143 ± 264 A	b 1428 ± 468 A	b 3657 ± 778 B
Duodenal mucosa
Iron deficient	a 132 ±  46 A		a 143 ±  44 A
Iron adequate	a 142 ±  14 A	a 143 ±  27 A	a 176 ±  44 A
Iron overload	b 470 ±  53 A	b 472 ± 127 A	b 621 ± 126 A
Spleen
Iron deficient	a 935 ± 211 A		a 1919 ± 438 B
Iron adequate	b 2132 ± 365 A	a 2214 ± 533 A	a 2337 ± 484 A
Iron overload	c 3813 ± 291 A	b 3108 ± 373 A	b 3260 ± 631 A
Kidney
Iron deficient	a 292 ±  21 A		a 344 ±  28 A
Iron adequate	a 387 ± 120 A	a 330 ±  77 A	a 356 ±  63 A
Iron overload	a 378 ±  93 A	a 386 ±  53 A	a 394 ±  71 A

Numbers in parentheses correspond to number of animals assayed or number of determinations performed. Groups in the same row that have no capital letter in common are significantly different from each other, as are lowercase letters, which indicate significant differences between various states of iron repletion (ANOVA; P < 0.05). See Materials and Methods for details.