Table 2. p53 status in oesophageal adenocarcinoma.
|
Mutations in p53 |
||||||
|---|---|---|---|---|---|---|
| Sample | Exon | Codon | Base change | Amino-acid substitution | P53 IHCa | p53 deletion (% of cells) |
| 1 | + | |||||
| 2 | +++ | |||||
| 3 | 0 | |||||
| 4 | +++ | |||||
| 5 | +++ | |||||
| 6 | +++ | |||||
| 7 | 7 | 245 | GGC → GAC | Gly → Asp | ++ | |
| 7 | 247 | AAC → AAT | Asn → Asn | |||
| 8 | NA | NA | ||||
| 9 | ++ | |||||
| 10 | +++ | |||||
| 11 | +++ | |||||
| 12 | +++ | |||||
| 13 | ++ | 17.5 | ||||
| 14 | +++ | 14.5 | ||||
| 15 | +++ | 24.0 | ||||
| 16 | 0 | |||||
| 17 | 0 | |||||
| 18 | 0 | 21.5 | ||||
| 19 | +++ | |||||
| 20 | +++ | 14.0 | ||||
| 21 | 7 | 249 | AGG → GGG | Arg → Gly | +++ | |
| 22 | +++ | |||||
| 23 | + | 14.0 | ||||
| 24 | +++ | |||||
| 26 | +++ | |||||
| 28 | 0 | 14.0 | ||||
| 29 | 6 | 214 | CAT → CGT | His → Arg | +++ | |
| 30 | +++ | |||||
| 31 | +++ | |||||
| 32 | +++ | |||||
| 33 | NA | NA | ||||
NA indicates samples that were unavailable for the immunohistochemical and FISH analyses; all blank cells indicate no p53 mutations or deletions (above the cutoff percentage) were found in the samples.
a
p53 immunohistochemistry: 0=immuno-negative; +=weak; ++=moderate; +++=strong p53 staining.