Table 3. Adjusted risk ratio for solid tumor before and after 20 years of age in the offspring, according to parental preconception exposure to atomic bomb radiation.
|
Age 1–19 years |
Age 20+ years |
|||||||
|---|---|---|---|---|---|---|---|---|
| Dose (mSv) | No. of casesa | Risk ratio | 95% CI | P-valueb | No. of casesa | Risk ratio | 95% CI | P-valueb |
| Paternal exposure | ||||||||
| 0–4 (reference) | 4 | 1.00 | 0.78 | 156 | 1.00 | 0.60 | ||
| 5–49 | 3 | 0.80 | (0.17–3.68) | 25 | 0.99 | (0.63–1.49) | ||
| 50–149 | 23 | 0.89 | (0.55–1.35) | |||||
| 150–499 | 27 | 1.09 | (0.71–1.63) | |||||
| 500–4000 | 16 | 0.68 | (0.39–1.10) | |||||
| Unknown | 34 | 1.12 | (0.76–1.61) | |||||
| Continuous dose (100 mSv) | ||||||||
| 1.03 | (0.84–1.14) | 0.66 | 0.96 | (0.92–1.00) | 0.07 | |||
| Maternal exposure | ||||||||
| 0–4 (reference) | 11 | 1.00 | 0.97 | 256 | 1.00 | 0.99 | ||
| 5–49 | 11 | 0.98 | (0.42–2.31) | 43 | 0.89 | (0.63–1.23) | ||
| 50–149 | 48 | 0.97 | (0.70–1.31) | |||||
| 150–499 | 49 | 1.02 | (0.74–1.38) | |||||
| 500–4000 | 34 | 1.02 | (0.70–1.43) | |||||
| Unknown | 43 | 0.99 | (0.70–1.36) | |||||
| Continuous dose (100 mSv) | 1.02 | (0.88–1.12) | 0.73 | 1.01 | (0.98–1.04) | 0.53 | ||
a
In all, 55 offspring who developed solid cancer were conceived after both parents had been irradiated.
b
Test for homogeneity of risk ratios among dose groups or test for trend of linear dose response; baseline rates adjusted for city, sex, year of birth, residency, and age at entry.