Table 4. Adjusted risk ratio for hematopoietic tumor before and after 20 years of age in the offspring, according to parental preconception exposure to radiation.
|
Age 1–19 years |
Age 20+ years |
|||||||
|---|---|---|---|---|---|---|---|---|
| Dose (mSv) | No. of casesa | Risk ratio | 95% CI | P-valueb | No. of casesa | Risk ratio | 95% CI | P-valueb |
| Paternal exposure | ||||||||
| 0–4 (reference) | 7 | 1.00 | 0.47 | 11 | 1.00 | 0.86 | ||
| 5–49 | 7 | 1.07 | (0.36–3.13) | 3 | 1.68 | (0.37–5.60) | ||
| 50–149 | 1 | 0.58 | (0.03–3.06) | |||||
| 150–499 | 2 | 1.10 | (0.17–4.21) | |||||
| 500–4000 | 1 | 0.63 | (0.03–3.28) | |||||
| Unknown | 0 | Not estimated | ||||||
| Continuous dose (100 mSv) | 0.97 | (0.73–1.09) | 0.70 | 0.91 | (0.65–1.07) | 0.36 | ||
| Maternal exposure | ||||||||
| 0–4 (reference) | 7 | 1.00 | 0.14 | 23 | 1.00 | 0.90 | ||
| 5–49 | 10 | 1.55 | (0.59–4.28) | 4 | 0.96 | (0.28–2.53) | ||
| 50–149 | 3 | 0.66 | (0.16–1.92) | |||||
| 150–499 | 6 | 1.40 | (0.51–3.24) | |||||
| 500–4000 | 3 | 0.99 | (0.23–2.87) | |||||
| Unknown | 3 | 0.72 | (0.17–2.10) | |||||
| Continuous dose (100 mSv) | 1.04 | (0.89–1.13) | 0.58 | 0.97 | (0.83–1.07) | 0.63 | ||
a
6 offspring who developed hematopoietic tumor were conceived after both parents had been irradiated.
b
Test for homogeneity of risk ratios among dose groups or test for trend of linear dose response; baseline rates adjusted for city, sex, year of birth, residency, and age at entry.