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. 2003 Oct 28;89(9):1599–1604. doi: 10.1038/sj.bjc.6601326

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Copyright © 2003 Cancer Research UK

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Tree structured classifier for predicting the unknown class of a tissue specimen when four classes are possible. Binary classifier A based on gene expression profile is first used to predict whether the specimen is in subset {I,III} or in subset {II,IV} of classes. For those specimens predicted to be in subset {I,III}, binary classifier B is used to predict whether the specimen is in class I or III. For those specimens predicted to be in subset {II,IV} based on classifier A, binary classifier C is used to predict whether the specimen is in class II or IV. The three binary classifiers will generally utilise different gene sets for prediction.