Table 5. Adverse events during intralesional IL-2 therapy, graded according to WHO criteria.

Adverse event WHO grade	I	II	III	IV
Local erythema and slight swelling	24 (100%)	0	0	0
Fever	1 (4%)	13 (54%)	0	0
Flu-like symptoms	8 (33)	6 (25%)	0	0
Pain	7 (29)	9 (38%)	0	0
Fatigue	11 (46%)	0	0	0
Nausea/vomiting	8 (33%)	2 (8%)	0	0
Stomach pain	4 (17%)	0	0	0
Diarrhoea	2 (8%)	1 (4%)	0	0
Headache	2 (8%)	0	1 (4%)	0
Muscle cramp	1 (4%)	0	0	0
Tachykardia	1 (4%)	0	0	0

Number of patients and incidence rate.