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. 2003 Oct 28;89(9):1766–1775. doi: 10.1038/sj.bjc.6601346

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Copyright © 2003 Cancer Research UK

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Induction of cell-cycle arrest by gefitinib. After 48 h of incubation with gefitinib, CM cells (A) and BON cells (B) dose-dependently accumulated in the G0/G1-phase of the cell cycle. Accordingly, the proportion of cells in the S and G2/M phases decreased in either cell line. In contrast, no significant changes of cell-cycle phases were observed in STC-1 cells (C). Means±s.e.m. of four independent experiments for each cell line are shown. The difference of the proportion of cells in a particular phase of the cell cycle vs control was significant for 7.5–10 μM gefitinib in CM cells and for 10–50 μM gefitinib in BON cells. ^* Statistical significance (P<0.05).