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. 2003 Nov 11;89(10):1817–1821. doi: 10.1038/sj.bjc.6601327

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Copyright © 2003 Cancer Research UK

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Perturbations in the extracellular proteolytic axis can lead to dysregulation of cell dissociation, cell death, and cell division, the three D's of tumorigenesis. Shown are the molecules currently known to be processed by metalloproteinases. These are linked to the loss of cell adhesion underlying loss of cell contact inhibition and EMT, evasion of cell death, and aberrant cell proliferation.

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