Table 1. Effects of l-deprenyl (D) and clorgyline (C) on the survival of four clonogenic cell lines.
|
Plating efficiency (% of control) |
|||||
|---|---|---|---|---|---|
| Radiation dose (Gy) | MAOI | HaCaT cells | HaCaT-ras cells | HPV-G cells | PC3 cells |
| 0 | 0 | 100 (28.6±2.5) | 100 (56.7±4.4) | 100 (23.4±2.1) | 100 (11.9±1.3) |
| 0.5 | 0 | 81.3±5.4 | 100±5.2 | 65.7±3.3 | 80.4±3.4 |
| 5 | 0 | 17.4±1.1 | 20.6±3.3 | 19.9±1.7 | 17.5±1.2 |
| 0 | D | 154±3.8 | 112±3.1 | 120±3.8 | 102±5.6 |
| 0.5 | D | 165±3.5 | 98±5.2 | 103±4.8 | 89.2±7.7 |
| 5 | D | 82±4.9 | 17.9±3.7 | 21.0±2.1 | 20.4±3.6 |
| 0 | C | 170±5.7 | 90.1±4.0 | 97.5±2.7 | 96.6±2.7 |
| 0.5 | C | 149±6.6 | 77.3±3.5 | 99.2±3.7 | 75.1±4.8 |
| 5 | C | 79.0±4.3 | 12.5±3.4 | 20.0±1.7 | 19.0±2.3 |
All cell lines were set up in a medium containing the indicated monoamine oxidase inhibitor (MAOI) at a concentration of 1 nM and irradiated 6 h later. All plating efficiencies are expressed relative to the control, which received no radiation, D or C.