Table 2. Delayed reproductive death (clonogenic survival of subcultured cells) in distant progeny of cells whose progenitors were exposed to 1 nMl-deprenyl or 1 nM clorgyline.
|
Survival of progeny (% of control) |
||||
|---|---|---|---|---|
| Radiation dose (Gy) | MAOI | HaCaT cells | HaCaT-ras cells | HPV-G cells |
| Control 0 | None | 100 (27.0±3.1) | 100 (96.1±3.3) | 100 (16.0±1.1) |
| Control 0.5 | None | 100 (22.2±2.7) | 100 (57.2±3.9) | 100 (11±0.6) |
| Control 5.0 | None | 100 (6.5±0.4) | 100 (57.9±2.9) | 100 (10±0.4) |
| 0 | l-Deprenyl | 138±7.3 | 60.0±4.1 | 120±8.9 |
| 0.5 | l-Deprenyl | 127±6.4 | 120±10.3 | 196±0.7 |
| 5.0 | l-Deprenyl | 200±13.1 | 90.1±3.7 | 126.3±6.7 |
| 0 | Clorgyline | 104±5.4 | 64.3±2.8 | 75.6±3.4 |
| 0.5 | Clorgyline | 123±3.8 | 110±7.1 | 116±8.2 |
| 5.0 | Clorgyline | 133±6.1 | 90.6±2.8 | 126±7.7 |
The clonogenic assay was performed on cultures that had undergone at least 15 population doublings postexposure.