Figure 1.

Segregation of CHEK2 1100delC mutation in four families with HPC. 1100delC variant carriers are denoted by a plus sign (+), and noncarriers by a minus sign (−). An asterisk (^*)) denotes the persons with no sample available. No sample was available from affected father (II-2) in family 351, but because the mother (II-1) did not carry the mutation, the father is a likely 1100delC mutation carrier. Current age of the unaffected members or age at diagnosis for prostate cancer patients (in years) is indicated below the symbol for each family member. In each family, the index patient is marked with an arrow. Squares denote male subjects, and circles denote female subjects; black symbols denote patients with prostate cancer.