Table 2. Simvastatin PK parameters following oral administration of 40 mg simvastatin alone and combined with oral administration of 400 mg imatinib.
| Simvastatin plus imatinib | Simvastatin alone | |
|---|---|---|
| tmax (h)a | 1.0 (0.5–3.0) | 1.0 (0.5–4.0) |
| Cmax (ng ml−1) | 42.3±25.8 | 23.3±23.8 |
| t1/2 | 2.7±1.3 | 1.4±0.8 |
| AUC(0–all) (ng h ml−1) | 136.4±113.6 | 45.5±61.1 |
| AUC(0–∞) (ng h ml−1) | 137.7±110.2 | 47.2±60.4 |
| Vz/F(l) | 1543.0±810.9 | 3115.9±2749.9 |
| CL/F (l h−1) | 504.1±431.8 | 2000.3±1975.3 |
a
Median (range). All unflagged values are mean±s.d. Mean and s.d. values are shown.