Table 2. Chemotherapy and radiotherapy dose and schedule modifications for toxicity^a.

Toxicity	Modification
Chemotherapy
Grade ⩾3 leukopenia, granulocytopenia, thrombocytopenia, on days 8 or 36	Docetaxel and cisplatin withheld
Grade ⩾3 leukopenia, granulocytopenia, thrombocytopenia, on day 29	Chemotherapy postponed until toxicity recovered to grade 2
Grade 2 leukopenia, granulocytopenia, thrombocytopenia on day 8, 29, or 36	Doses of both drugs reduced by 5 mg m−2
24-h creatinine clearance 30–60 ml min−1, or serum creatinine 1.5–2.0 mg dl−1	Cisplatin dose reduced to 30 mg m−2
Creatinine clearance <30 ml min−1, or serum creatinine >2.0 mg dl−1	Cisplatin withheld
Systemic oedema or fluid retention on day of chemotherapy administration	Docetaxel withheld
Nonhaematologic grade ⩾3 toxicity, except for hair loss or nausea/vomiting	Chemotherapy postponed until recovery
Radiotherapy
Grade ⩾3 radiation oesophagitis	Radiation withheld until recovery to grade ⩽2
Lung toxicity (10 Torr↓PaO2 from baseline)	Radiation withheld until PaO2 decrease is <10 Torr
Grade 3 granulocytopenia with infection or grade 4 leukopenia or granulocytopenia	Radiation discontinued and rhG-CSF (2 μg kg−1) administered until leucocyte count ⩾5000 μl−1 or neutrophil count ⩾2000 μl−1
Grade ⩾3 thrombocytopenia	Radiation withheld until platelet count ⩾25 000 μl−1

^aChemotherapy and radiotherapy were discontinued if toxicities did not resolve within 12 weeks.