Table 5. Nonhaematologic toxicities (phase II portion) (n=42).
|
No. of patients with grade |
|||||||
|---|---|---|---|---|---|---|---|
| 0 | 1 | 2 | 3 | 4 | 5 | % of toxicities grade ⩾3 | |
| Nausea/vomiting | 9 | 13 | 15 | 5 | 0 | 0 | 11.9 |
| Diarrhoea | 28 | 6 | 5 | 2 | 1 | 0 | 7.1 |
| Stomatitis | 37 | 4 | 0 | 0 | 1 | 0 | 2.4 |
| Neurologic | 40 | 2 | 0 | 0 | 0 | 0 | 0 |
| Liver | 38 | 1 | 2 | 1 | 0 | 0 | 2.4 |
| Renal dysfunction | 41 | 1 | 0 | 0 | 0 | 0 | 0 |
| Fever | 36 | 1 | 5 | 0 | 0 | 0 | 0 |
| Alopecia | 2 | 28 | 12 | — | — | — | — |
| Oesophagitis | 13 | 12 | 9 | 7 | 1 | 0 | 19.0 |
| Pneumonitis | 38 | 3 | 0 | 1 | 0 | 1 | 4.8 |
Nonhaematologic toxicity was assessed and graded using ECOG common toxicity criteria (Oken et al, 1982), and grading of acute oesophageal and pulmonary toxicities due to radiation was in accordance with RTOG/EORTC radiation acute toxicity criteria (Cox et al, 1995).