Table 1. Summary of all studies since 1990 with more than 20 ACIS patients in relation with hr-HPV and/or coexisting CIN.
| Author and year | Patients (n) | hr-HPV pos | HPV 16 | HPV 18 | Coexisting CIN |
|---|---|---|---|---|---|
| Riethdorf et al (2002) | 42 | 32 | 22 | 10 | ND |
| (76%) | (53%) | (24%) | |||
| Madeleine et al (2001) | 82 | 71 | 32 | 43 | ND |
| (87%) | (39%) | (52%) | |||
| Riethdorf et al (2000) | 33 | 29 | 21 | 8 | 14 |
| (88%) | (64%) | (24%) | (42%) | ||
| Pirog et al (2000) | 23 | 23 | 10 | 6 | 9 |
| (100%) | (43%) | (26%) | (39%) | ||
| Anciaux et al (1997) | 21 | 16 | 6 | 10 | 9 |
| (76%) | (29%) | (47%) | (43%) | ||
| Duggan et al (1994) | 37 | 23 | 8 | 15 | ND |
| (66%) | (23%) | (43%) | |||
| Higgins et al (1992) | 42 | 39 | 13 | 28 | 22 |
| (95%) | (31%) | (67%) | (52%) | ||
| Leary et al (1991) | 30 | 21 | 10 | 11 | 15 |
| (70%) | (33%) | (37%) | (50%) | ||
| Bekkers et al (present study) | 96 | 85 | 39 | 41 | 49 |
| (89%) | (41%) | (43%) | (51%) |
ACIS=adenocarcinoma in situ; hr-HPV= high-risk human papillomavirus; CIN=cervical intraepithelial neoplasia; HPV=human papillomavirus; ND=not documented.