. 2003 Aug 26;89(5):930–936. doi: 10.1038/sj.bjc.6601189

Table 1. Peptides inhibition constants (K_i in nM).

	Human OTR	Human V1a	Human V1b	Human V2
LVT	2.40±0.425	30.8±4.2	24.9±7.3	2593±625
dLVT	3.88±0.585	35.5±6.2	71.7±2.0	3737±400
DOTA-dLVT	1.21±0.199	370±58	640±177	3562±280

Binding of LVT-derived peptides to human OT/AVP receptor subtypes. Competition experiments were performed using membrane preparations of COS7 cells transiently transfected with the wild-type human OTR, and V1a, V1b and V2 receptors. The K_i values for the human OTR were obtained by displacement of [³H]-OT; the K_i values for the human V1a, V1b and V2 receptors were obtained by displacement of [³H]-AVP. The values are the mean values±s.e. of three different experiments each performed in triplicate.

Table 1. Peptides inhibition constants (Ki in nM).

Table 1. Peptides inhibition constants (K_i in nM).