Table 1. Age-related changes in gene expression in RPE/choroid.
| Name | Description | Gene Bank | Fold Change | p value | No. |
| Leukocyte Extravasation Signaling | |||||
| CXCR4 | chemokine (C-X-C motif) receptor 4 | D87747 | 2.9 | 0.000242 | 3 |
| CYBA | cytochrome b-245, alpha polypeptide | AK018713 | 2.3 | 5.79E-05 | 3 |
| CYBB | cytochrome b-245, beta polypeptide | AV373944 | 2.9 | 3.30E-05 | 3 |
| ICAM1 | intercellular adhesion molecule 1 (CD54) | BC008626 | 2.1 | 6.26E-05 | 3 |
| ITGAL | integrin, alpha L (antigen CD11A (p180) | BI554446 | 2.6 | 0.00041451 | 3 |
| ITGAM | integrin, alpha M (complement component 3 receptort) | NM_008401 | 3.4 | 0.00017275 | 3 |
| ITGB2 | integrin, beta 2 (complement component 3 receptor) | NM_008404 | 3.2 | 8.51E-05 | 3 |
| MMP3 | matrix metallopeptidase 3 (stromelysin 1, progelatinase) | NM_010809 | 12.2 | 1.85E-05 | 3 |
| MMP12 | matrix metallopeptidase 12 (macrophage elastase) | BC019135 | 2.1 | 0.001043 | 3 |
| MMP13 | matrix metallopeptidase 13 (collagenase 3) | NM_008607 | 9.1 | 0.00031966 | 3 |
| MMP19 | matrix metallopeptidase 19 | NM_021412 | 2.4 | 0.0034653 | 3 |
| NCF1 | neutrophil cytosolic factor 1 | AI844633 | 2.5 | 6.61E-05 | 3 |
| NCF2 | neutrophil cytosolic factor 2 | NM_010877 | 2.1 | 0.00073191 | 2 |
| NCF4 | neutrophil cytosolic factor 4 | NM_008677 | 2.6 | 0.00037003 | 3 |
| PIK3R5 | phosphoinositide-3-kinase, regulatory subunit 5 | AV230647 | 3.0 | 0.00031618 | 3 |
| PTK2B | PTK2B protein tyrosine kinase 2 beta | NM_172498 | 2.1 | 0.00013604 | 3 |
| RAC2 | rho family, small GTP binding protein Rac2 | NM_009008 | 2.4 | 0.00020253 | 3 |
| RASSF5 | Ras association (RalGDS/AF-6) domain family 5 | NM_018750 | 2.1 | 0.00058134 | 3 |
| THY1 | Thy-1 cell surface antigen | NM_009382 | 2.1 | 0.00023721 | 2 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | BC008107 | 2.3 | 0.00039729 | 3 |
| TIMP4 | TIMP metallopeptidase inhibitor 4 | BI788452 | 3.8 | 3.32E-05 | 3 |
| VAV1 | vav 1 oncogene | NM_011691 | 2.6 | 5.35E-05 | 3 |
| VCAM1 | vascular cell adhesion molecule 1 | L08431 | 2.5 | 5.04E-05 | 3 |
| CLDN5 | claudin 5 | NM_013805 | −2.1 | 0.0041074 | 1 |
| Complement Cascades | |||||
| C3 | complement component 3 | K02782 | 9.4 | 3.47E-05 | 3 |
| C1QA | complement component 1, q subcomponent, A chain | NM_007572 | 2.3 | 6.61E-05 | 3 |
| C1QB | complement component 1, q subcomponent, B chain | NM_009777 | 2.6 | 5.24E-05 | 3 |
| C1QC | complement component 1, q subcomponent, C chain | NM_007574 | 2.9 | 5.84E-05 | 3 |
| C1R | complement component 1, r subcomponent | NM_023143 | 2.5 | 9.70E-06 | 3 |
| C1S | complement component 1, s subcomponent | BC022123 | 2.4 | 5.24E-05 | 3 |
| C3AR1 | complement component 3a receptor 1 | NM_009779 | 2.1 | 6.61E-05 | 3 |
| C4B | complement component 4B | NM_009780 | 2.3 | 6.49E-05 | 3 |
| CFB | complement factor B | NM_008198 | 2.2 | 3.73E-05 | 1 |
| PLAUR | plasminogen activator, urokinase receptor | NM_011113 | 2.4 | 0.0055312 | 2 |
| NK cell Signaling | |||||
| CER1G | Fc fragment of IgE, high affinity I, receptor for | NM_010185 | 2.4 | 3.30E-05 | 3 |
| FCGR3A | Fc fragment of IgG, low affinity IIIa, receptor (CD16a) | BC027310 | 2.7 | 0.0014469 | 3 |
| LAIR1 | leukocyte-associated immunoglobulin-like receptor 1 | AV370380? | 3.5 | 0.00030431 | 3 |
| LCK | lymphocyte-specific protein tyrosine kinase | NM_010693 | 2.2 | 0.00045097 | 2 |
| PIK3R5 | phosphoinositide-3-kinase, regulatory subunit 5, p101 | AV230647 | 3.0 | 0.00031618 | 3 |
| RAC2 | rho family, small GTP binding protein Rac2 | NM_009008 | 2.4 | 0.00020253 | 3 |
| H3BP2 | SH3-domain binding protein 2 | BC010198 | 2.6 | 0.00024365 | 3 |
| SYK | spleen tyrosine kinase | AW907526 | 2.4 | 0.00012293 | 3 |
| YROBP | TYRO protein tyrosine kinase binding protein | NM_011662 | 2.3 | 3.30E-05 | 3 |
| VAV1 | vav 1 oncogene | NM_011691 | 2.6 | 5.35E-05 | 3 |
| IL-10 Signaling | |||||
| ARG2 | arginase, type II | NM_009705 | 2.0 | 0.0039292 | 1 |
| CCR1 | chemokine (C-C motif) receptor 1 | AV231648 | 2.9 | 0.00083896 | 3 |
| CGR2B | Fc fragment of IgG, low affinity IIb, receptor (CD32) | BM224327 | 3.3 | 5.79E-05 | 3 |
| FCGR3 | Fc fragment of IgG, low affinity III | NM_010188 | 2.5 | 0.00024334 | 3 |
| HMOX1 | heme oxygenase (decycling) 1 | NM_010442 | 2.4 | 0.00071255 | 2 |
| IL10RA | interleukin 10 receptor, alpha | NM_008348 | 2.6 | 6.15E-05 | 3 |
| IL1RN | interleukin 1 receptor antagonist | M57525 | 3.4 | 6.61E-05 | 3 |
Shown are the differentially expressed genes in the 4 most significantly changed pathways in aged RPE/choroid by Limma analysis. Fold changes compare old vs. young. “No.” means the number of statistical methods (Limma, Dchip and SAM) in which each gene appeared changed. See Table S1 online for a complete list of gene expression changes in the RPE/choroid of old animals.