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. Author manuscript; available in PMC: 2009 Feb 1.

Published in final edited form as: J Mol Cell Cardiol. 2007 Nov 12;44(2):361–369. doi: 10.1016/j.yjmcc.2007.10.022

Tempol and overexpression of Cu/Zn SOD or MnSOD preserve NO-induced inhibition of migration in VSMC exposed to HG. A: Summary of cell migration in uninfected VSMC exposed to high glucose showing that treatment with Tempol has no effect on migration of cells in the absence of SNAP, but protects the ability of SNAP to inhibit migration of cells exposed to HG. N=3, *P<0.05, two-way ANOVA. B: Infection of cells with adenoviral vectors to overexpress Cu/Zn SOD and MnSOD preserved the ability of IL-1β induced iNOS to inhibit migration in VSMC exposed to HG. N=3, *P<0.05, two-way ANOVA. C: Tempol prevents the decrease in b-IAM labeling of SERCA in uninfected VSMC exposed to high glucose. The bar graph summarizes densitometry data from 3 independent experiments. *P<0.05, one-way ANOVA.

Tempol and overexpression of Cu/Zn SOD or MnSOD preserve NO-induced inhibition of migration in VSMC exposed to HG. A: Summary of cell migration in uninfected VSMC exposed to high glucose showing that treatment with Tempol has no effect on migration of cells in the absence of SNAP, but protects the ability of SNAP to inhibit migration of cells exposed to HG. N=3, *P<0.05, two-way ANOVA. B: Infection of cells with adenoviral vectors to overexpress Cu/Zn SOD and MnSOD preserved the ability of IL-1β induced iNOS to inhibit migration in VSMC exposed to HG. N=3, *P<0.05, two-way ANOVA. C: Tempol prevents the decrease in b-IAM labeling of SERCA in uninfected VSMC exposed to high glucose. The bar graph summarizes densitometry data from 3 independent experiments. *P<0.05, one-way ANOVA.

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