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. Author manuscript; available in PMC: 2009 Feb 1.
Published in final edited form as: J Mol Cell Cardiol. 2007 Nov 12;44(2):361–369. doi: 10.1016/j.yjmcc.2007.10.022

Figure 4.

Figure 4

High glucose prevents the ability of NO to decrease calcium-dependent association of calmodulin (CaM) with PP2B. The upper panel shows that immuno-precipitated CaM is associated with less PP2B in VSMC treated with DETA-NONOate when the cells were exposed to NG, but not HG for 3 d. Immuno-blot showed that similar amounts of CaM were contained in the immuno-precipitate. The bar graph in the lower panel summarizes the ratio of the densitometric values detected by the PP2B antibody with that by the CaM antibody in 3 independent experiments. These data show that NO decreases the association of CaM-PP2B in NG, but not in HG. *P<0.05, two-way ANOVA.

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