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. Author manuscript; available in PMC: 2009 Jan 1.
Published in final edited form as: Aging Cell. 2007 Nov 20;7(1):23–31. doi: 10.1111/j.1474-9726.2007.00350.x

Fig. 2.

Fig. 2

Osteoblast differentiation is impaired in mouse bone marrow stromal cells (BMSCs) derived from G3 single (Wrn−/− or Terc−/−) and double (Wrn−/−/Terc−/−) mutants. (a) Detection of alkaline phosphatase (Alk P) activity and mineralization (Mineral) is shown for BMSCs isolated from 10-month-old animals. (b) Quantitation of osteogenic potential and osteoblast differentiation in BMSCs. Shown are the number of colony-forming units–fibroblast (CFU–F), colony size, alizarin red S positive colonies (AR+), and alkaline phosphatase positive (AlkP+) colonies for the indicated genotypes.