TABLE 4.

Search for the Ideal Antifungal Agent

A more complete understanding of the pathogenesis of invasive fungal infections

Virulence factors (e.g., adhesins) as targets for new antifungals and vaccines

Identification of new compounds (natural and synthetic)

Traditional screening against fungal pathogens

Identification of new targets by genomic analysis (signature)

Enhance efficacy and reduce toxicity of older antifungal drugs

Improved delivery systems (Lipid AMB, aerosols)

High-throughput and reproducible susceptibility testing

A better understanding of the mechanisms of resistance to antifungal drugs

Intrinsic vs Acquired

Combination therapy - synergy

AMB + 5FC for cryptococcal meningitis

AMB + voriconazole for aspergillosis

Echinocandins + voriconazole for filamentous moulds

Immune enhancement therapy

Monoclonal antibodies

Manan binding lectins replacement