Table 4.
Results (undiscounted) of sensitivity analyses for varying compliance rates
| Compliance | No screening | Screening for type 2 diabetes only | Screening for type 2 diabetes and impaired glucose tolerance | |
|---|---|---|---|---|
| Lifestyle interventions | Pharmacological interventions | |||
| Compliance with screening (%) | ||||
| QALY: | ||||
| 100 | 28.06 (23.49 to 32.01) | 28.12 (23.58 to 32.08) | 28.26 (23.74 to 32.23) | 28.22 (23.69 to 32.18) |
| 70 | 28.06 (23.49 to 32.01) | 28.07 (23.52 to 32.05) | 28.17 (23.64 to 32.16) | 28.14 (23.60 to 32.13) |
| 50 | 28.06 (23.49 to 32.01) | 28.04 (23.51 to 32.04) | 28.13 (23.61 to 32.13) | 28.10 (23.59 to 32.11) |
| Total cost (£): | ||||
| 100 | 17 290 (5746 to 39 580) | 18 040 (7083 to 39 970) | 17 910 (7124 to 39 740) | 17 900 (7061 to 39 710) |
| 70 | 17 290 (5746 to 39 580) | 18 070 (6777 to 39 800) | 18 080 (6957 to 39 620) | 18 070 (6907 to 39 710) |
| 50 | 17 290 (5746 to 39 580) | 17 870 (6409 to 39 750) | 17 930 (6705 to 39 680) | 17 910 (6671 to 39 690) |
| Cost (£) per QALY gained: | ||||
| 100 | — | 8681 | 2863 | 3429 |
| 70 | — | 8732 | 3112 | 3800 |
| 50 | — | 8743 | 3515 | 4192 |
| Probability of being cost effective at willingness to pay threshold of £20 000/£30 000 per QALY (%): | ||||
| 100 | — | 68/76 | 99/100 | 95/97 |
| 70 | — | 69/77 | 98/99 | 93/96 |
| 50 | — | 68/77 | 97/98 | 92/95 |
| Compliance with interventions (%) | ||||
| QALY: | ||||
| 100 | 28.06 (23.49 to 32.01) | 28.12 (23.58 to 32.08) | 28.26 (23.74 to 32.23) | 28.22 (23.69 to 32.18) |
| 70 | 28.06 (23.49 to 32.01) | 28.12 (23.58 to 32.08) | 28.22 (23.69 to 32.18) | 28.19 (23.66 to 32.15) |
| 50 | 28.06 (23.49 to 32.01) | 28.12 (23.58 to 32.08) | 28.19 (23.66 to 32.15) | 28.17 (23.64 to 32.13) |
| Total cost (£): | ||||
| 100 | 17 290 (5746 to 39 580) | 18 040 (7083 to 39 970) | 17 910 (7124 to 39 740) | 17 900 (7061 to 39 710) |
| 70 | 17 290 (5746 to 39 580) | 18 040 (7083 to 39 970) | 18 140 (7343 to 39 950) | 18 040 (7209 to 39 880) |
| 50 | 17 290 (5746 to 39 580) | 18 040 (7083 to 39 970) | 18 261 (7455 to 40 050) | 18 120 (7302 to 39 960) |
| Cost (£) per QALY gained: | ||||
| 100 | — | 2863 | 3429 | |
| 70 | — | 4947 | 5039 | |
| 50 | — | 6634 | 6243 | |
| Probability of being cost effective at willingness to pay threshold of £20 000/£30 000 per QALY (%): | ||||
| 100 | — | 99/100 | 95/97 | |
| 70 | — | 94/97 | 89/94 | |
| 50 | — | 88/93 | 84/90 | |