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. 2008 Mar 15;22(6):711–721. doi: 10.1101/gad.1643908

Figure 2.

Figure 2.

Interaction of GHR and GR signaling through STAT5 in hepatocytes. STAT5B is activated upon binding of GH to its receptor by the associated JAK2. Tyrosine-phosphorylated STAT5B dimers bind to GAS and induce transcription of the negative regulators SOCS2 and SOCS3. SOCS2 and SOCS3 modulate signaling from the GHR and gp-130 receptors, respectively. Transcription of IFG-1 and metabolic genes is induced through additional signals from the GR and depends on the direct interaction of GR and STAT5B tetramers. (G) Glucocorticoid; (gp) glycoprotein.