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. Author manuscript; available in PMC: 2009 Apr 10.
Published in final edited form as: Neuron. 2008 Apr 10;58(1):89–103. doi: 10.1016/j.neuron.2008.01.033

Figure 2.

Figure 2

Paradoxical presynaptic potentiation (PPP). (A) A METH challenge in vivo decreases corticostriatal release in saline-treated controls (higher destaining halftime) but increases release on withdrawal day 10 following repeated METH. n=185–325 puncta per condition; ***p<0.01 compared to control without METH, !! p<0.01 compared to withdrawal without METH, Mann-Whitney. (B) Repeated METH at 10 and 20 mg/kg/day inhibits individual terminal responses on withdrawal day 10. An AMPH challenge 10 days following repeated METH at 10- (C) and 20 mg/kg/day (D) potentiated release from all terminals. Release half-times (t1/2) in slices from control (E) and METH–treated mice (F) on withdrawal day 10 following cortical stimulation at 1 Hz, 10 Hz and 20 Hz in the presence and absence of AMPH in vitro. ***p<0.001, Mann-Whitney.

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