Figure 1.

Matching the S100 sequence against the EBI databases. (a) Some of the matching sequences found by the MSDtarget pairwise alignment. Those with associated three-dimensional models are shown in green. (b) The pairwise alignment for one of the models, 1irj. (c) The overlap, based on one chain only, of the final S100 dimer model, 1e8a, onto the 1irj dimer. The two chains of the S100 dimer are shown in green and blue and those of the 1irj dimer in yellow and tan. Clearly, the second chains do not match well. (d) The overlap of 1e8a onto the 1mho dimer using the same colour scheme. Although the matched chains do not fit so well, the relative orientation of the monomers is closer than that for 1irj.