Table 2. P1 buried surface area/activity relationship.

The inhibitors have the generic formula of 9 except with a t-Boc cap instead of tert-butylurea.

Compd	P1	Ki*	SA	SA	Rel. Ki* SA	Rel. Ki* exp.	Ki* ratio exp./SA
2	Abu	740	82	0	1	1	1.0
3	Nva	100	120	38	18	7	0.4
4	Nle	160	136	54	63	5	0.1
5	c-Pra	25	125	43	27	30	1.1
6	c-Bua	25	141	59	93	30	0.3