Table 3. P2 buried surface area/activity relationship (generic formula 9).
| Compd | P2 | Ki* | SA | SA | Rel. Ki* SA | Rel. Ki* exp. | Ki* ratio exp./SA |
|---|---|---|---|---|---|---|---|
| 7 | Pro | 5000 | 25 | 0 | 1 | 1 | 1.0 |
| 8 | Leu | 1000 | 63 | 38 | 19 | 5 | 0.3 |
| 9 | DMCP | 14 | 83 | 58 | 86 | 360 | 4.1 |
| 10 | DCCP | 19 | 70 | 45 | 32 | 260 | 8.1 |
| 11 | DFCP | 140 | 51 | 26 | 7 | 36 | 4.8 |