Table 4. P3 buried surface area/activity relationship (generic formula 9, except 12 and 13 have P1 = c-Pra rather than c-Bua).

Compd	P3	Ki*	SA	SA	Rel. Ki* SA	Rel. Ki* exp.	Ki* ratio exp./SA
12	Val	100	37	0	1.0	1	1.0
13	Chg	50	55	18	4.0	2	0.5
9	t-Bug	14	34	3	0.8	7	9.0