Table 5. P4 buried surface area/activity relationship (generic formula 9, except P3= Chg rather than t-Bug).

Compd	P4	Ki*	SA	Rel. Ki* SA	Rel. Ki* exp.	Ki* ratio exp./SA
14	MeO(CO)	800	0	1	1	1.0
15	EtO(CO)	230	22	5	3	0.6
16	iPrO(CO)	60	52	54	13	0.2
5	tBuO(CO)	25	52	54	32	0.6
17	Ac-Val	68	55	68	12	0.2