Table 2. Comparison of the performance of four common molecular-replacement programs on two test cases of data.

	AMoRe	MOLREP	EPMR	Phaser
H. pylori DHQase (F23), Z = 1
Correct solution	Yes	Yes	No	Yes
R factor/CC†	0.46/0.42	0.51/0.33 (0.48/0.38‡)	0.54/0.20	0.46/0.43
Computation time	54min	1h 13min	23min§	4min
S. coelicolor DHQase (P1), Z = 192
Correct solutions	Yes (16)	Yes (14)	Yes (11)	Yes (16)
R factor/CC†	0.37/0.77	0.55/0.51 (0.41/0.74‡)	0.51/0.54	0.33/0.88
Computation time	57min	5h 12min	2d 16h§	30d 6h

^†All R factors and correlation coefficients were calculated from output coordinates using REFMAC5 for consistency.

^‡After six cycles of rigid-body refinement using REFMAC5 with data to 4.

^§Using all four processors of the computer.