Table 2. Inhibition constant (K i values) of elafin (Zani et al., 2004 ▶) and 50% inhibitory concentrations (IC50) of 1/2SLPI and against some serine proteases (Masuda et al., 1994 ▶).
| K i (M) of elafin | IC50 of 1/2SLPI | |
|---|---|---|
| 57 amino acids A1G57 | 49 amino acids R58A107 | |
| 42% identity with 1/2SLPI | C-terminal domain of SLPI | |
| H. neutrophil elastase | 1 1010 | 1.3 108 |
| P. pancreatic elastase | 1 109 | 3.3 105 |
| H. cathepsin G | 8.0 109 | |
| B. pancreatic chymotrypsin | 8.0 109 | |
| B. pancreas trypsin | 2.0 106 |