Figure 4.

Solution of the structure of thioredoxin peroxidase B (TPx-B) from human erythrocytes. Sections of the SRF corresponding to rotations by (a) 180° and (b) 72° indicate the 52 point-group symmetry of the TPx-B molecule and define the orientations of NCS fivefold and twofold axes. (c) The hORF06 dimer, a building block of the search model. (d) The search model with two variable parameters, the angle ω and the distance R. (e) Two sections of a two-dimensional search space crossing the point corresponding to the correct decamer: the highest CC in the TF search versus ω and versus R. (f) The final decameric TPx-B structure. This figure was prepared using MOLREP, CCP4mg, BOBSCRIPT and R.