TABLE 3.
Pathological and microbiological findings following challenge of calves with M. bovis
| Vaccine group | Proportiona of animals with:
|
Mean lesion scores ± SEM in:
|
Mean no. of M. bovis culture-positive LNs/animal ± SEM | ||
|---|---|---|---|---|---|
| Lung lesions | LNb lesions | Lungsc | LNsd | ||
| Nonvaccinated | 7/10 | 10/10 | 3.1 ± 0.7 | 7.8 ± 1.1 | 2.5 ± 0.3 |
| BCG alone | 5/10 | 4/10e | 1.1 ± 0.4e,f | 2.2 ± 1.1e | 1.6 ± 0.4 |
| BCG-CFP-DDA-PIM2 | 3/10 | 2/10e | 0.9 ± 0.5e,f | 0.9 ± 0.6e,f | 1.7 ± 0.4 |
| BCG-CFP-DDA-MPL | 3/10 | 5/10e | 0.6 ± 0.4e,f | 1.3 ± 0.6e | 1.7 ± 0.3 |
| BCG-CFP-DDA-Pam3CSK4 | 1/10e,f | 2/10e | 0.3 ± 0.3e,f | 0.2 ± 0.1e,f | 1.3 ± 0.4e,f |
| BCG-DDA-MPL | 8/10 | 7/10 | 2.5 ± 0.5 | 3.8 ± 1.2e | 2.5 ± 0.3 |
The data represent the number of animals with lung or lymph node lesions/total number of animals in the group.
LN, lymph node.
Lung lesion scores: 0, no lesions; 1, 1 to 9 lesions; 2, 10 to 29 lesions; 3, 30 to 99 lesions; 4, 100 to 199 lesions; 5, ≥200 lesions.
Total lymph node lesion score per animal for individual nodes: 0, no lesions; 1, 1 to 19 small lesions (diameter, 1 to 4 mm); 2, ≥20 small lesions; 3, medium-size lesions (diameter, 5 to 9 mm); 4, large lesions (diameter, ≥10 mm). Scores for the four pulmonary lymph nodes for each animal were pooled.
The results are significantly different from those for the nonvaccinated group (P < 0.05).
The results are significantly different from those for the BCG-DDA-MPL group (P < 0.05).