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. Author manuscript; available in PMC: 2009 Jun 1.
Published in final edited form as: Front Neuroendocrinol. 2008 Feb 7;29(3):344–357. doi: 10.1016/j.yfrne.2008.01.003

Fig. 5.

Fig. 5

The sex and genotype of siblings in the litter influences metabolic activity in the limbic landscape of adult mice wildtype (WT) or knockout (KO) for the estrogen receptor α gene. Limbic landscapes of ♂WT or ♂KO (or ♀WT or ♀KO) raised with brothers or sisters of the same or different genotype are depicted; sex/genotype on left of diagonal is the experimental individual while sex/genotype on right of diagonal is the type of sibling it was raised with. Illustrated is the mean cytochrome oxidase (CO) abundance in specific brain nuclei. The limbic landscape maps on the bottom row are the difference between the ♂WT/♂WT and ♀WT/♀WT and between ♂KO/♂KO and ♀KO/♀KO maps, respectively, indicating the effect of the sibling’s sex independent of genotype. The left column are maps indicating the difference between the effect of ♂WT/♂WT and ♂KO/♂KO and between ♀WT/♀WT and ♀KO/♀KO, respectively, indicating the effect of the siblings genotype independent of sex. See Fig. 4 for further details.