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. Author manuscript; available in PMC: 2008 May 23.
Published in final edited form as: Pharmacol Biochem Behav. 2007 Jul 25;88(1):105–113. doi: 10.1016/j.pbb.2007.07.011

Fig. 2.

Fig. 2

Effect of baclofen on 1 h DID in C57BL/6J mice (n=18–20 per baclofen dose). Each animal received two different doses of baclofen, and the corresponding effects of each dose on ethanol and water intake were considered independent observations for the purposes of statistical analysis. A. Baclofen dose-dependently increased binge-like ethanol intake during the 1 h ethanol access period. This effect reached significance at the 10 mg/kg baclofen dose (p<0.001). B. Baclofen dose-dependently increased blood ethanol concentration during the 1 h ethanol access period. The peak effect of baclofen occurred at the 10 mg/kg dose (p<0.01). C. Baclofen did not significantly alter water intake.

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