Fig. 3.

Effect of muscimol on 1 h DID in C57BL/6J mice (n=16–20 per muscimol dose). Each animal received two different doses of muscimol, and the corresponding effects of each dose on ethanol and water intake were considered independent observations for the purposes of statistical analysis. A. Muscimol dose-dependently reduced binge-like ethanol intake during the 1 h ethanol access period. This effect reached significance at all the doses tested (p’s<0.05). B. Muscimol dose-dependently decreased blood ethanol concentration during the 1 h ethanol access period following a similar pattern as that of ethanol intake (p’s<0.001). C. Muscimol significantly reduced water intake at all the doses tested (p’s<0.01).