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. Author manuscript; available in PMC: 2008 May 23.
Published in final edited form as: Pharmacol Biochem Behav. 2007 Jul 25;88(1):105–113. doi: 10.1016/j.pbb.2007.07.011

Fig. 4.

Fig. 4

Effect of THIP on 1 h DID in C57BL/6J mice (n=18–20 per THIP dose). Each animal received two different doses of THIP, and the corresponding effects of each dose on ethanol and water intake were considered independent observations for the purposes of statistical analysis. A. THIP dose-dependently reduced binge-like ethanol intake during the 1 h ethanol access period. This effect reached significance at the two highest doses tested in male and female mice (p’s<0.05). B. THIP dose-dependently decreased blood ethanol concentration during the 1hr ethanol access period following the same pattern as the ethanol intake data (p’s<0.05). C. THIP significantly reduced water intake at the 8 and 16 mg/kg doses (p’s<0.001).

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