FIG. 6.

Flux profiles for three highlighted situations from the sensitivity analysis of Fig. 5. Fluxes (in moles) are normalized for a glucose uptake of 100 mol. Arrows indicate the direction of the (net) flux. In case of reversible reactions, the exchange flux is included in parentheses. Some arrows are dashed to improve readability. Metabolites present in both compartments are differentiated by the indicators “cyt” (cytosol) and “mit” (mitochondrion). Upper numbers in each set of three, malic enzyme and net cytosolic malate dehydrogenase fluxes forced to 0; middle numbers, malic enzyme flux forced to 0; lower numbers, malic enzyme flux forced to the value obtained for the best fit and net cytosolic malate dehydrogenase flux forced to 0.