TABLE 3.
Mean ratios of expression for virus-infected relative to virus-free Drosophila
| Gene function and name | GeneID | Relative expression level (virus-infected flies/virus-free flies)a
|
|||
|---|---|---|---|---|---|
| SIGMAVb | DCV
|
DXVe | |||
| Oral infection routec | Intrathoracic infection routed | ||||
| Upstream genes and receptors | |||||
| PGRP-SA | CG11709 | x | − | 3.2 | ND |
| PGRP-SB1 | CG9681 | 23.5 | − | − | ND |
| PGRP-SC1a, PGRP-SC1b | CG14746, CG8577 | − | − | − | ND |
| PGRP-SD | CG7496 | 3.5 | − | − | ND |
| PGRP-LC | CG4432 | − | − | − | ND |
| Toll | CG5490 | − | − | − | ND |
| Spaetzle | CG6134 | ND | − | 3.0 | ND |
| Signaling cascade | |||||
| Relish | CG11992 | − | − | 3.5 | ND |
| vir-1 | CG31764 | − | − | 6.4 | ND |
| Antimicrobial peptides | |||||
| Drosomycin-B | CG10810 | − | 3.0 | 2.1 | 70 |
| Defensin | CG1385 | − | − | + | 4.8 |
| Metchnikowin | CG8175 | − | − | 3.0 | 60 |
| Drosocin | CG10816 | 10.3 | − | − | 3.2 |
| Diptericin-A | CG12763 | 5.6 | − | − | 3.2 |
| Diptericin-B | CG10794 | ND | − | 5.0 | ND |
| Attacin-A | CG10146 | 7.2 | 6.3 | 8.7 | 2.5 |
| Attacin-B | CG18372 | ND | − | 4.7 | ND |
| Attacin-C | CG4740 | ND | − | 2.7 | ND |
| Attacin-D | CG7629 | ND | − | + | ND |
| Cecropin-A1 | CG1365 | 8.8 | 2.6 | − | 1.8 |
| Cecropin-A2 | CG1367 | ND | 3.3 | − | ND |
| Cecropin-B | CG1878 | ND | − | + | ND |
| Cecropin-C | CG1373 | ND | − | + | ND |
a
−, no difference in expression levels; x, no detectable expression; ND, not determined; +, induced expression relatively to virus-free flies.
b
qRT-PCR data from this study; data reported for P values <0.05.
c
Microarray data from reference 28.
d
Microarray data from reference 13.
e
qRT-PCR data from reference 35.