TABLE 3.
Virulence gene transcripts regulated by heme in S. aureus ΔhrtA
| Locusa | Fold change in hemeb | Gene namec | Description of product |
|---|---|---|---|
| NWMN_0388 | 11.3 | set1nm | Staphylococcal superantigen-like toxin NM1 |
| NWMN_0389 | 6.9 | set2nm | Staphylococcal superantigen-like toxin NM2 |
| NWMN_0392 | 16.1 | set5nm | Staphylococcal superantigen-like toxin NM5 |
| NWMN_0393 | 8.9 | set6nm | Staphylococcal superantigen-like toxin NM6 |
| NWMN_0394 | 14.0 | set7nm | Staphylococcal superantigen-like toxin NM7 |
| NWMN_0395 | 6.7 | set8nm | Staphylococcal superantigen-like toxin NM8 |
| NWMN_0396 | 9.4 | set9nm | Staphylococcal superantigen-like toxin NM9 |
| NWMN_0397 | 6.9 | set10nm | Staphylococcal superantigen-like toxin NM10 |
| NWMN_1077 | 6.0 | Staphylococcal superantigen-like toxin | |
| NWMN_1503 | 3.7 | Enterotoxin type A, putative | |
| SACOL0857 | 20.4 | Staphylocoagulase precursor, putative | |
| SACOL1168 | 32.3 | fbp | Fibrinogen-binding protein |
| SACOL1169 | 29.3 | Fibrinogen-binding protein precursor-related protein | |
| SACOL1924 | 2.4 | Toxin-exporting ABC transporter, permease/ATP-binding protein | |
| SACOL2511 | 4.8 | fnbA | Fibronectin-binding protein A |
| SACOL2584 | 23.7 | isaA | Immunodominant antigen A |
| SACOL0137 | −11.5 | cap5B | Capsular polysaccharide biosynthesis protein |
| SACOL0138 | −11.2 | cap5C | Capsular polysaccharide biosynthesis protein |
| SACOL0143 | −8.3 | cap5H | Capsular polysaccharide biosynthesis protein |
| SACOL1637 | −42.1 | lukD | Leukotoxin LukD |
| SACOL1865 | −20.8 | splE | Serine protease SplE |
| SACOL1866 | −22.2 | splD | Serine protease SplD |
| SACOL1867 | −9.1 | splC | Serine protease SplC |
| SACOL1872 | −12.3 | epiE | Epidermin immunity protein F |
| SACOL1873 | −17.3 | epiF | Epidermin immunity protein F |
| SACOL2007 | −8.7 | Peptidase, M20/M25/M40 family | |
| SACOL2419 | −52.8 | hlgA | Gamma hemolysin, component A |
| SACOL2421 | −80.9 | hlgC | Gamma hemolysin, component C |
| SACOL2422 | −42.4 | hlgB | Gamma hemolysin, component B |
All genes with SACOL designation are from S. aureus strain COL; because of strain specificity exhibited by toxins, all S. aureus superantigen-like toxins are referenced with S. aureus strain Newman locus designations (NWMN).
All virulence gene transcripts with at least twofold changes in S. aureus ΔhrtA exposed to heme compared to S. aureus ΔhrtA alone which are statistically significant are shown. Underlining indicates that in S. aureus ΔhrtA alone, the transcript abundance approaches the lower limit of sensitivity and thus values may not be accurate. Bold indicates that in S. aureus ΔhrtA alone, no transcript was detected and thus values may not be accurate.
Transcripts with no gene name have no designated name in the S. aureus COL genome annotation.