TABLE 5.
Secondary metabolite-biosynthetic gene clusters (or genes) of S. griseus IFO 13350
| Gene clustera | Product and/or type |
|---|---|
| Known | |
| SGR5914-SGR5940 | Streptomycin (aminoglycoside) |
| SGR4238-SGR4250 | Grixazone (phenoxazinone) |
| SGR6824-SGR6830 | Isorenieratene (carotenoid) |
| SGR6619-SGR6620 | HPQ melanin (by type III PKS) |
| SGR470-SGR472 | Alkylresorcinol (by type III PKS) |
| SGR1268-SGR1269 | 2-Methylisoborneol (by terpene cyclase) |
| Predicted | |
| Terpene | |
| SGR54t-SGR60t | Carotenoid |
| SGR7085t-SGR7079t | Carotenoid |
| SGR962-SGR966 | Hopanoid |
| SGR2079 | Terpene |
| SGR6065 | Terpene |
| SGR6839 | Germacradienol/geosmin |
| PKS and NRPS | |
| SGR443-SGR455 | NRPS for siderophore |
| SGR574-SGR593 | NRPS |
| SGR653-SGR656 | NRPS |
| SGR895-SGR901 | NRPS |
| SGR2586-SGR2598 | NRPS |
| SGR6709-SGR6717 | NRPS for siderophore |
| SGR6730-SGR6742 | NRPS for siderophore |
| SGR6071-SGR6083 | Type I PKS |
| SGR6177-SGR6183 | Type I PKS |
| SGR6360-SGR6387 | Type I PKS |
| SGR604-SGR611 | Enediyne PKS |
| SGR278-SGR283 | PKS-NRPS hybrid |
| SGR810-SGR815 | PKS-NRPS hybrid |
| SGR2482-SGR2489 | Type I PKS, NRPS |
| SGR6776-SGR6786 | Type I PKS, PKS-NRPS hybrid |
| SGR3239-SGR3288 | Type II PKS, NRPS |
| Others | |
| SGR4747-SGR4751 | Nocardamine (siderophore) |
| SGR527-SGR528 | Melanin |
| SGR2446-SGR2447 | Melanin |
| SGR3845-SGR3849 | Lantibiotic |
| SGR4408-SGR4421 | Lantibiotic |
| SGR5285-SGR5295 | Unknown |
a
The range of clusters for unknown compounds was predicted on the basis of possible gene function, putative transcriptional units, synteny, and/or our transcriptome data.