FIG. 3.

The methylmalonyl pathway enables bypass of the glyoxylate shunt during growth of M. tuberculosis on propionate. (A) Growth of H37Rv on propionate in the presence of 3NP with (□) or without (▪) vitamin B₁₂ supplementation versus the growth of the ΔprpDC mutant on vitamin B₁₂-supplemented propionate with (▵) or without (▴) 3NP. (B) Growth of the ΔmutAB mutant on vitamin B₁₂-supplemented propionate with (⋄) or without (⧫) 3NP. Data are OD₆₀₀ values for a single representative experiment from three independent biological replicates.